PURPOSE: The purpose of this study was to identify predictors of spiritual well-being and meaning in life for adolescents with leukemia. METHODS: Participants were 102 adolescents (11-21 years) recruited at C university hospital from June to August in 2014. The eligible participants were diagnosed with leukemia and are on follow-up care at the outpatient clinic. Participants were assessed for spiritual well-being, meaning in life, self-esteem, and social support. RESULTS: Levels of spiritual well-being and meaning in life for these adolescents with leukemia were 3.69 out of 6 and 3.10 out of 4, respectively. Self-esteem and social support from family were factors affecting spiritual well-being. Self-esteem, existential well-being and social support from family and friends were predictive for meaning in life and accounted for 68% of total variance. CONCLUSION: The results show that there are several factors affecting spiritual well-being and meaning in life in adolescents with leukemia. Therefore, nursing intervention programs for adolescents with leukemia should include strengthening self-esteem and social support as well as considering the spiritual aspect of life in order to find meaning in life beyond leukemia.