Clinical Psychopharmacology and Neuroscience  2011;9(1):23-28

Clinical Predictors of Drug Response in Patients with Obsessive-Compulsive Disorder.

Chan Hyung KIM 1 ; Jae Wook JEONG ; Eun Ju KIM ; Yoon Shick SHIN ; Ho Suk SUH ; Hong Shick LEE ; Min Seong KOO

Affiliations

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Keywords

Obsessive-compulsive disorder; Clinical predictors; Drug response; Treatment duration

Country

Republic of Korea

Language

English

Abstract

OBJECTIVE: The aim of this study was to evaluate which clinical variables might influence the antiobsessional responses to proserotonergic drugs in a sample of patients with obsessive-compulsive disorder (OCD). METHODS: Two hundred forty-nine patients with DSM-IV OCD under-gone mean 13-month treatments with selective serotonin reuptake inhibitors. According to the treatment response, defined as a reductions of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score > or =35%, patients were divided into two groups. RESULTS: One hundred fourteen patients responded to the treatment and the other one hundred thirty five patients did not. Responders had a significant long duration of medication in YUMC OCD clinic, short total duration of past treatment in other institutes, and higher frequency of drug naive cases and lower baseline Y-BOCS scores. CONCLUSION: The pre-treatment factors including total duration of past treatment, drug naive or not, baseline OCD symptoms and the factor of duration of the treatment may influence drug treatment response in OCD patients.