The Journal of the Korean Rheumatism Association  2007;14(3):268-273

doi:10.4078/jkra.2007.14.3.268

Successful Treatment of Interstitial Pneumonitis Induced by Leflunomide.

Dong Hyuk SHEEN 1 ; Mi Kyoung LIM ; Seung Cheol SHIM ; Sang Ok LEE ; Seong Wook KANG ; Ju Kyung SONG ; You Sun LEE

Affiliations

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Keywords

Leflunomide; Interstitial pneumonitis; Rheumatoid arthritis

Country

Republic of Korea

Language

Korean

Abstract

Leflunomide is a disease-modifying antirheumatic drug that has been available in Korea since 2003. Leflunomide induced interstitial pneumonitis has been reported as an adverse effect in other countries but not in Korea. A 57-year-old woman was treated with leflunomide since she had been resistant to methotrexate, hydroxychloroquine and sulfasalazine. She developed high fever, dyspnea, and non-productive cough 3 months after the administration of leflunomide. She was diagnosed leflunomide-induced interstitial pneumonitis based on history, physical, laboratory, radiologic and pathologic findings. The patient was treated by prednisolone 1 mg/kg/day with cholestyramine 24 g/day, resulting in dramatic improvement. Here we report a case of leflunomide induced pneumonitis treated successfully with high dose steroid.