Asian Spine Journal  2013;7(3):227-231

doi:10.4184/asj.2013.7.3.227

Giant Invasive Sacral Schwannoma Showing Chromosomal Numerical Aberrations -14,+18,+22.

Masahiko KANAMORI 1 ; Taketoshi YASUDA ; Takeshi HORI ; Kayo SUZUKI

Affiliations

+expand

Keywords

Sacrum; Neurilemmoma; Cytogenetics

Country

Republic of Korea

Language

English

Abstract

Here, we report on a rare case of a giant invasive sacral schwannoma. The patient was a 58-year-old woman who had a 6-year history of non-specific buttock pain. Histological investigation confirmed the diagnosis of cellular schwannoma. The following numerical aberration was detected using the GTG-banding method for karyotypes: 47,XX,-14,+18,+22. Cytogenetic studies of schwannomas have indicated a complete or partial loss of chromosome 22 as the most common abnormality, but this case is cytogenetically rare because of the recurrence of trisomy 22.