Journal of Liver Cancer  2016;16(1):57-62

doi:10.17998/jlc.2016.16.1.57

Regression of Advanced Hepatocellular Carcinoma with Lung Metastasis in Response to Sorafenib.

Dae Ha KIM 1 ; Gee Ho MIN ; Dong Won LEE ; Ke Ryun AHN ; Ji Hye KIM ; Sang Jun SUH ; Young Kul JUNG ; Hyung Joon YIM

Affiliations

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Keywords

Carcinoma, Hepatocellular; Drug therapy; Sorafenib; Treatment outcome

Country

Republic of Korea

Language

Korean

Abstract

Sorafenib is a multi-targeted tyrosine kinase inhibitor that inhibits Raf kinase and the vascular endothelial growth factor receptor intracellular kinase pathway and is the first agent to demonstrate a statistically significant improvement in overall survival for patients with advanced hepatocellular carcinoma (HCC). However, there were few cases of partial or complete response reported in the previous studies. We herein report a case of dramatic partial response in a patient who had advanced HCC with multiple lung metastasis and portal vein thrombosis treated with sorafenib.