Journal of Stroke  2016;18(3):267-272

doi:10.5853/jos.2016.00206

Neural Stem Cells and Ischemic Brain.

Zhenggang ZHANG 1 ; Michael CHOPP

Affiliations

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Keywords

Adult neurogenesis; Stroke; Brain repair; Stem cells

Country

Republic of Korea

Language

English

Abstract

Stroke activates neural stem cells in the ventricular-subventricular zone (V/SVZ) of the lateral ventricle, which increases neuroblasts and oligodendrocyte progenitor cells (OPCs). Within the ischemic brain, neural stem cells, neuroblasts and OPCs appear to actively communicate with cerebral endothelial cells and other brain parenchymal cells to mediate ischemic brain repair; however, stroke-induced neurogenesis unlikely plays any significant roles in neuronal replacement. In this mini-review, we will discuss recent findings how intercellular communications between stroke-induced neurogenesis and oligodendrogenesis and brain parenchymal cells could potentially facilitate brain repair processes.