Journal of the Korean Surgical Society  2008;74(4):312-315

Mesenteric Fibromatosis Presenting as a Submucosal Tumor of the Jejunum.

Changyoung YOO 1 ; Chan Kwon JUNG ; Kyo Young SONG ; Eun Sun JUNG ; Kyo Young LEE

Affiliations

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Keywords

Mesenteric fibromatosis; beta-catenin; Immunohistochemistry; Small intestine

Country

Republic of Korea

Language

Korean

Abstract

Mesenteric fibromatoses occur as sporadic lesions or as parts of familial adenomatous polyposis, are clonal lesions prone to locally aggressive behavior, but lack metastatic capacity. Fibromatoses harbor somatic beta-catenin or adenomatous polyposis coli (APC) mutations, leading to intranuclear accumulation of b-catenin. We report a case of mesenteric fibromatosis presenting as a 5.4x4.8 cm submucosal tumor of the jejunum in a 42-year-old woman. Histologically, the tumor consisted of proliferation of bland, elongated-spindle fibroblasts with collagen deposition and a characteristic prominent vasculature. Immunohistochemically, the tumor cells showed nuclear staining for beta-catenin. Mesenteric fibromatosis should be included in the differential diagnosis of submucosal spindle cell tumors of the gastrointestinal tract, and nuclear immunoreactivity for beta-catenin may help distinguish these tumors form histological mimics.