Laboratory Medicine Online  2012;2(4):226-231

doi:10.3343/lmo.2012.2.4.226

Mycoplasma pneumoniae Pneumonia Unresponsive to Macrolide Treatment.

Misuk JI 1 ; Heungsup SUNG ; Tae Sun SHIM ; Woori JANG ; Mi Na KIM

Affiliations

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Keywords

Community-Acquired Pneumonia; Mycoplasma pneumoniae; Macrolide; Resistance

Country

Republic of Korea

Language

Korean

Abstract

We present a case of community-acquired pneumonia (CAP) that developed in a previously healthy young woman. She was diagnosed with Mycoplasma pneumoniae pneumonia, but did not respond to macrolide treatment. The pathogens of CAP was examined using chest radiographs, computed tomography, and various laboratory tests including Mycoplasma IgG and IgM antibodies, blood and sputum cultures, and PCR for M. pneumoniae, Legionella pneumophila, and Chlamydophila pneumoniae. In this study, differential diagnosis of the pathogens and analysis of the mechanisms underlying their resistance to macrolide treatment were performed, and the results were discussed. After changing the antimicrobial to quinolone, the patients' clinical symptoms and radiographic findings improved, and she was discharged after 8 days.