Journal of Clinical Neurology  2007;3(2):108-111

doi:10.3988/jcn.2007.3.2.108

Central Nervous System Lymphomatoid Granulomatosis Presenting with Parkinsonism.

Eun Hee SOHN 1 ; Chang Joon SONG ; Hyo Jin LEE ; Samyong KIM ; Jae Moon KIM ; Ae Young LEE

Affiliations

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Keywords

Lymphomatoid granulomatosis; Parkinsonism; Magnetic resonance imaging

Country

Republic of Korea

Language

English

Abstract

Lymphomatoid granulomatosis (LG) is a potentially malignant lymphoproliferative disorder. The lung is the most common involved site, followed by the skin and nervous system. However, LG of the central nervous system presenting with Parkinsonism is very rare. We report a patient with LG who presented with parkinsonian features such as bilateral rigidity, bradykinesia, and agitation. Brain magnetic resonance imaging showed multifocal punctuate enhanced lesions in both supra- and infratentorial areas. Steroid pulse therapy resulted in a dramatical improvement in the symptoms and MRI abnormalities.