Korean Journal of Gastrointestinal Endoscopy  2007;34(6):339-342

Tuberculous Meningitis in a Patient with Crohn's Disease, Which was Treated with Infliximab.

Youn Ho KIM 1 ; Beom Jae LEE ; Jong Jae PARK ; Won Woo LEE ; Woo Sik HAN ; Sung Nam OH ; Do Won CHOI ; Jae Seon KIM ; Young Tae BAK ; Hee Jin CHEONG

Affiliations

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Keywords

Crohn's disease; Tuberculous meningitis; Infliximab

Country

Republic of Korea

Language

Korean

Abstract

Clinical trials of tumor necrosis factor (TNF) inhibitor have demonstrated significant efficacy in those patients with Crohn's disease that is not responsive to other anti-inflammatory drug. Infliximab is a human-murine chimeric monoclonal antibody with a high binding affinity and specificity for TNF-alpha. Yet therapy with infliximab is associated with an increased risk of opportunistic infection, and especially tuberculosis. Here we reported on a case of tuberculous meningitis in 26-year-old man, and he was treated with infliximab for uncontrolled and fistulous Crohn's disease. We also include a review of the literature.