Obstetrics & Gynecology Science  2017;60(5):477-480

doi:10.5468/ogs.2017.60.5.477

BRCA1-mutated ovarian cancer with skin metastasis: a case report.

So Ra OH 1 ; Jung Woo PARK ; Hyun Young KWON ; Seo Hee RHA

Affiliations

+expand

Keywords

Skin metastases; Ovarian neoplasms; BRCA mutation

Country

Republic of Korea

Language

English

Abstract

The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of BRCA-mutated OCs is limited. Herein, we describe a case of OC with a BRCA1 mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously.