Endocrinology and Metabolism  2011;26(4):348-354

doi:10.3803/EnM.2011.26.4.348

A Case of Cushing's Disease in Pregnancy.

Jeong Tae KIM 1 ; Mun Hyuk SUNG ; Woo Ri PARK ; Jeong Ho HAN ; Hye Suk HAN ; Young Kwang SIM ; Tae Gun OH ; Hyun Jeong JEON

Affiliations

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Keywords

Cushing's disease; Cushing's syndrome; Pregnancy

Country

Republic of Korea

Language

Korean

Abstract

Developing Cushing's syndrome during pregnancy is rare because menstruation is irregular and hypercortisolism causes infertility. Developing Cushing's disease during pregnancy is very rare because there is even less ovulation than those with the adrenal adenoma. The clinical manifestations of Cushing's syndrome may easily be missed during pregnancy as the features of weight gain, hypertension, and hyperglycemia overlap with those that occur during a pregnancy. Diagnosing Cushing's syndrome during a pregnancy is complex because the biochemical features are obscured by the natural changes in the hypothalamic-pituitary-adrenal axis that occur during pregnancy. Having Cushing's syndrome during a pregnancy results in increased fetal and maternal complications, so early diagnosis and treatment are critical. We report the clinical and endocrine findings of a pregnant women with Cushing's disease who underwent transsphenoidal surgery after delivery.