International Journal of Oral Biology  2014;39(2):75-79

Antimicrobial Effects of Oleanolic Acid, Ursolic Acid, and Sophoraflavanone G against Enterococcus faecalis and Propionibacterium acnes.

Eojin JO 1 ; Mi Hwa CHOI ; Hwa Sook KIM ; Soon Nang PARK ; Yun Kyong LIM ; Christina K KANG ; Joong Ki KOOK

Affiliations

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Keywords

antimicrobial effect; oleanolic acid; ursolic acid; sophoraflavanone G; Enterococcus faecalis; Propionibacterium acnes

Country

Republic of Korea

Language

Korean

Abstract

The aim of this study was to investigate antimicrobial effect of oleanolic acid (OA), ursolic acid (UA), and sophoraflavanone G against Enterococcus faecalis and Propionibacterium acnes, which are the major causative bacteria of endodontic infections. The antimicrobial activity was evaluated by the minimal inhibitory concentration (MIC). The data showed that the OA, UA, and sophoraflavanone G had antimicrobial effect on all the strains use in the study with 16-64 microg/ml, 8-64 microg/ml, and 1-8 microg/ml of MIC values, respectively. These results indicate that OA, UA, and sophoraflavanone G could be useful in the development of antiseptic solution for washing the root canal in endodontic treatments.