The Journal of the Korean Society for Transplantation  2000;14(1):101-108

Four Cases of Posttransplant Lymphoproliferative Disease (PTLD) Following Renal Transplantation.

Seung Hee CHOI 1 ; Jee Sook HAHN ; Yu Seun KIM ; Kiil PARK

Affiliations

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Keywords

Posttransplant lymphoproliferative disase; Renal transplantation

Country

Republic of Korea

Language

Korean

Abstract

Posttransplant lymphoproliferative disorder (PTLD) is now a well-documented and serious complication of organ transplantation, ranging from polyclonal lymphoid hyperplasia to malignant lymphoma. PTLD is due to the combined effects of lymphoid proliferation induced by Epstein-Barr virus (EBV) infection, and the disruption of normal immume control by cytotoxic T cells. It is also strongly related to the potency and the cumulative doses of immunosuppressants and the type of organ transplantation. We report four cases of PTLD after renal transplantation, for whom three cases were EBV-positive by in situ hybridization.