The Journal of the Korean Society for Transplantation  2000;14(1):109-114

A Case of Immune Hemolytic Anemia after Renal Transplantation.

Yong Ho CHOI 1 ; Ho Yun CHUNG ; Hyeon Ok PARK ; Joo Hyun PARK ; Hye Soo KIM ; Jong Min LEE ; Yong Soo KIM ; Suk Young KIM

Affiliations

+expand

Keywords

Immune hemolytic anemia; Kidney transplantation

Country

Republic of Korea

Language

Korean

Abstract

Several cases of immune hemolytic anemia have been reported after renal transplantation of ABO-minor-mismatch. We present a case of anti-B immune hemolytic anemia which developed on 11th day after renal transplantation. 48-year-old man, blood group Rh(+) AB, had a successful renal transplantation from his distant family, blood group Rh(+) A. He was maintained under immunosuppression with cyclosporine and prednisolone. On 11th day after renal transplantation he had a hemolytic episode. His hemoglobin dropped from 9.2 g/dl to 7.3 g/dl and corrected reticulocyte count increased to 3.7%. The peripheral blood morphology showed polychromatophilia, spherocytosis, and anisocytosis. Direct antiglobulin tests were positive with anti-IgG and anti-C3d. The antibody that caused hemolytic anemia was confirmed as anti-B IgG. The anti-B antibodies might be originated from passenger's donor B lymphocyte.