Korean Journal of Gynecologic Oncology and Colposcopy  1994;5(4):29-35

Two Cases of Glassy Cell Carcionma of the Cervix, Treated by Neoadjuvant Chemotherapy and Radical Hysterectomy.

Yoon Keun HUR ; Woo Gyeong KIM ; Moon Cheol RYU ; Yoo Sun MIN ; Ki Tae KIM ; Hyun Chan KIM

Country

Republic of Korea

Language

Korean

Abstract

Glassy cell carcinoma is a histologic subtype of cervical cancer with distinct pathologic features and it has an aggressive biologic course. It was first described by Glucksmann and Cherry in 1956 as a poorly differentiated adenoquamous carcinoma and commented on its poor prognosis, unresponsiveness to traditional modes of therapy, and often associated with pregnancy. The characteristic histologic features are defined as follows: 1) cells with a moderate amount of cytoplasm resembling ground glass, 2) a fairly distinct cell membrane that stains with eosin or PAS, 3) large nuclei with prominent nucleoli. We present two cases of glassy cell carcinoma of the cervix successfullyl treated by neoadjuvant chemotherapy and radical hyterectorny, with a brief review of literatures.