Anesthesia and Pain Medicine  2006;1(1):48-52

The Maternal and Neonatal Effect of Remifentanil in General Anesthesia for Cesarean Section.

Eui Min LEE 1 ; Dong Yeon KIM ; Rack Kyung CHUNG ; Guie Yong LEE

Affiliations

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Keywords

cesarean section; general anesthesia; remifentanil

Country

Republic of Korea

Language

Korean

Abstract

BACKGROUND: In case of general anesthesia for cesarean section, giving remifentanil has been described, but its maternal and neonatal effects and safety have not been investigated by a controlled study. METHODS: 20 healthy women undergoing elective cesarean section under general anesthesia at term were allocated randomly to receive remifentanil as effect site concentration of 3.0 ng/ml (R group, n = 10) and same amount of normal saline (C group, n = 10) just before endotracheal intubation. Each group was assessed for bispectral index (BIS), blood pressure, and heart rate at preinduction, arrival to target concentration, intubation, and 1 and 3 minutes after intubation and delivery. Neonatal effect was assessed by Apgar score at 1 and 5 minutes. RESULTS: The BIS of remifentanil group was lower than that of control group at 1 min after intubation (P < 0.05). The systolic blood pressure of remifentanil group were lower than those of control group at immediately after intubation (P < 0.05) and 1 min after intubation (P < 0.01). There were no significant differences in heart rate between two groups. CONCLUSIONS: We found that infusing remifentanil just before tracheal intubation was effective and safe to both mother and neonate.