Psychiatry Investigation  2009;6(3):230-232

A Case of Galactorrhea Associated with Excitalopram.

Se Hoon SHIM 1 ; Yeon Jeong LEE ; Eun Chan LEE

Affiliations

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Keywords

Escitalopram; Depression; Prolactin; Galactorrhea; Side effect

Country

Republic of Korea

Language

English

Abstract

Escitalopram is one of the most popular selective serotonin reuptake inhibitors (SSRIs) in current use as a first-line treatment for depression. Escitalopram is well-tolerated and rarely associated with serious side effects. Endocrine and reproductive side effects of serotonergic antidepressants are uncommon and galactorrhea is very rarely mentioned among SSRI-related side effects. Serotonin-enhancing antidepressants may result in a rise in prolactin levels through suppression of dopamine neurotransmission. In the present study, we report a case of hyperprolactinemic galactorrhea associated with escitalopram. A 36-year-old woman developed galactorrhea after initiation of escitalopram for depression and was found to have an elevated prolactin level. Escitalopram was discontinued with resolution of the patient's galactorrhea and normalization of her prolactin level.