Korean Journal of Blood Transfusion  2017;28(2):170-176

doi:10.17945/kjbt.2017.28.2.170

Revisiting the Pre-transfusion Test: A Case of Acute Hemolytic Transfusion Reaction due to Multiple Alloantibodies of Anti-E, Anti-c, Anti-Jk(b).

Gyu Dae AN 1 ; Kyeong Hee KIM ; In Hwa JEONG ; Hyeon Ho LIM ; Kwang Sook WOO ; Jin Yeong HAN ; Jeong Man KIM ; Jin Heon JEONG ; Young Ki SON

Affiliations

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Keywords

Hemolytic transfusion reaction; Pre-transfusion test; Unexpected antibody

Country

Republic of Korea

Language

Korean

Abstract

We report a case of acute hemolytic transfusion reaction due to multiple alloantibodies. A 41-year-old male with multiple histories of transfusion was admitted for jaundice and oliguria after receiving two units of red blood cells in a local clinic. He showed acute renal failure and disseminated intravascular coagulation. Direct Coombs test was negative and antibody screening test showed strong positive results. Anti-E, anti-c, and anti-Jk(b) antibodies were identified in two panels of unexpected antibody assays. Acute hemolytic transfusion was diagnosed, and he was discharged after 1 month of supportive treatment. Unexpected antibody detection tests, including the antiglobulin phase, should be performed to prevent adverse transfusion reactions by unexpected antibodies. Better precision and quality control are necessary when performing pre-transfusion tests.