Journal of the Korean Society of Echocardiography  2004;12(2):78-82

Short-Term Effect of High Dose of Vitamin C on Coronary Flow Velocity and Coronary Flow Reserve in Healthy Young Non-Smoker Men.

Moo Rim PARK 1 ; Jin Won JEONG ; An Saeng LEE ; Kyung Ho YUN ; Nam Jin YOO ; Sung Hee SHIN ; Eun Mi LEE ; Seok Kyu OH ; Nam Ho KIM ; Ock Kyu PARK

Affiliations

+expand

Keywords

Coronary circulation; Smokeless; Ascorbic acid

Country

Republic of Korea

Language

Korean

Abstract

BACKGROUND AND OBJECTIVES: Vitamin C, water-soluble antioxidant, has been reported to restore coronary microcirculatory responsiveness and impaired coronary flow reserve in smokers. However, the effect of high dose of vitamin C on coronary circulation is unclear in nonsmokers. METHODS: We used transthoracic echocardiography to measure the coronary flow reserve, an integrated measure of coronary flow in 20 male healthy nonsmokers (26+/-3 years) before and after administration of the high dose of vitamin C. RESULTS: The coronary peak diastolic velocity was increased by 14.8% after administration of antioxidant vitamin C, whereas the coronary flow reserve did not changed. CONCLUSION: High dose of vitamin C acutely increases the coronary flow velocity without restoration of coronary flow reserve in male healthy nonsmokers.