Genomics & Informatics  2013;11(1):38-45

doi:10.5808/GI.2013.11.1.38

Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis.

Kye Hwa LEE 1 ; Jae Hyeun LIM ; Ju Han KIM

Affiliations

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Keywords

acute myeloid leukemia; biolattice; concept lattice analysis; DNA mutational analysis; DNA sequence analysis; oncogenes

Country

Republic of Korea

Language

English

Abstract

In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukemia (AML). We selected 45 highly mutated genes with whole-exome sequencing in 10 normal matched samples of the AML-M2 subtype. To evaluate these genes, we performed concept lattice analysis and annotated these genes with existing knowledge databases.