Genomics & Informatics  2013;11(1):52-54

doi:10.5808/GI.2013.11.1.52

Eukaryotic DNAJ/K Database: A Comprehensive Phylogenomic Analysis Platform for the DNAJ/K Family.

Kyeongchae CHEONG 1 ; Jaehyuk CHOI ; Jaeyoung CHOI ; Jongsun PARK ; Suwang JANG ; Yong Hwan LEE

Affiliations

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Keywords

database; HSP40 heat-shock proteins; HSP70 heat-shock proteins

Country

Republic of Korea

Language

English

Abstract

Proteins in DNAJ/K families are ubiquitous, from prokaryotes to eukaryotes, and function as molecular chaperones. For systematic phylogenomics of the DNAJ/K families, we developed the Eukaryotic DNAJ/K Database (EDD). A total of 12,908 DNAJs and 4,886 DNAKs were identified from 339 eukaryotic genomes in the EDD. Kingdom-wide comparison of DNAJ/K families provides new insights on the evolutionary relationship within these families. Empowered by 'class', 'cluster', and 'taxonomy' browsers and the 'favorite' function, the EDD provides a versatile platform for comparative genomic analyses of DNAJ/K families.