Korean Journal of Perinatology  1997;8(4):433-436

A Case of Hemolyic Disease of Newborn Caused by Anti-c and Anti-E Antibody.

Chul Hong KIM ; Hwang Jae YOO ; Ik Jin SONG ; Jae Hong PARK ; Young Tak YIM

Keywords

Anti-c and Anti-E isoimmunization; Hemolytic disease of newborn; Minor blood group incompatibility

Country

Republic of Korea

Language

Korean

Abstract

Hemolytic disease of newborn due to Rhesus incompatibility occurs mostly by anti-Rh(D) antibodies. But recently, because of Rh(D) immune globuin prophylaxis, Rh(D) incompatibility is decreased and importance of minor group incompatibility is increasing. The majority of minor blood group incompatibilities are anti-c, anti-E or anti-Kell, but hemolytic diseases caused by combination of these antibodies are relatively rare. The 21 day-old male neonate was admitted because of pallor and poor feeding for 2 days. Laboratory data showed severe normochromic and normocytic anemia with increased reticulocyte and bilirubin. Patient's and his mothers blood type was B, Rh(D) positive. Minor blood groups of mother's and sons were different and anti-c and anti-E antibody were detected in mother's serum. After transfusions of two times with anti-c and anti-E free B, Rh(D) positive blood, the baby was discharged at 11th hospital day with good general condition.