Allergy, Asthma & Immunology Research  2017;9(3):281-284

doi:10.4168/aair.2017.9.3.281

A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test.

Jakyoung KIM 1 ; Shinyoung PARK ; Chul Min JUNG ; Chee Won OH ; Jae Woo KWON

Affiliations

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Keywords

Cycloserine; lichenoid eruptions; lymphocyte activation; drug hypersensitivity; drug eruptions

Country

Republic of Korea

Language

English

Abstract

Lichenoid drug eruption (LDE) is a rare form of delayed-type drug eruption. Among anti-tuberculosis (Tb) agents, cycloserine (CS) has been reported as a rare cause of LDE. Positive results on the lymphocyte transformation test (LTT) have not been reported in patients with LDE. In the present case, we performed LTT and a patch test, and successfully proved CS as the offending drug in this patient, who had been treated with multiple anti-Tb drugs. These observations suggest that CS should be considered a possible cause of LDE and that LTT can be an option for the diagnosis of LDE.