Korean Journal of Hepato-Biliary-Pancreatic Surgery  2009;13(2):114-119

Composite Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ampulla of Vater.

Bo Sung SOHN 1 ; Yu Hee NAM ; Jin A LEE ; Il Young PARK ; Nam Ik HAN ; Hee Jeong LEE

Affiliations

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Keywords

Large Cell Neuroendocrine Carcinoma; Adenocarcinoma; Ampulla of Vate

Country

Republic of Korea

Language

Korean

Abstract

Large Cell Neuroendocrine Tumors (LCNEC) in the ampulla of Vater are extremely rare. This report addresses a case of concurrent LCNEC and adenocarcinoma in the ampulla of Vater. A 60-year-old male patient experienced fever, body chills and jaundice. He had a periampullary ulcerative lesion and underwent radical pancreaticoduodenectomy. Histopathologically, the tumor consisted of an LCNEC component and an adenocarcinoma component. Simultaneous LCNEC and adenocarcinoma has been reported in a few cases. Our patient had a coexisting LCNEC and an adenocarcinoma of the ampulla of Vater. We also present a review of the literature