Journal of Asthma, Allergy and Clinical Immunology  1999;19(4):610-614

A case of intravenous immunoglobulin therapy in severe aspirin - sensitive asthma patient combined with IgG1 and IgG3 subclass deficiency.

Hae Sim PARK ; Hee Yeon KIM ; Dong Ho NAHM ; Sang Yong YOO ; Sung Gyun AHN ; Dong Suk HAN

Keywords

asthma; IgG subclass deficiency; intravenous immunoglobulin

Country

Republic of Korea

Language

Korean

Abstract

Common complications in a patient with IgG subclass deficiency include recurrent respiratory infections and concomitant inflammatory lung disease. The most effective therapy in these patients is the administration of intravenous immunoglobulin. The authors report a case of severe aspirin-sensitive asthma and recurrent pneumonia with combined IgG1, and IgG3 subclass deficiency in a 19-year-old man. The patient was treated with 0.4g/kg at monthly intervals for 6 months, and is still receiving 0.2g/kg every 2 weeks at our clinic. After the replacement of intravenous immunoglobulin, the patient has clinically improved.