PURPOSE: The purpose of this study was to explore perception of the clinical learning environment, resilience and perfectionism in relation to practice burnout and to identify factors influencing practice burnout in student nurses. METHODS: A descriptive correlational study was conducted. The participants were 313 student nurses from three universities in B and U city. Data were analyzed using t-test, ANOVA, Pearson correlation coefficient, Scheffés test and multiple regression analysis. RESULTS: Mean score for practice burnout in student nurses was 2.92 out of 5 points. Practice burnout explained 44.7% of the variance in perfectionism (β =.245, p<.001), satisfaction with college life (β =.232, p<.001), resilience (β =−.228, p<.001), clinical learning environment (β =−.193, p<.001), satisfaction with major (β =.180, p=.001), practical relationships with peers (β =.128, p=.005), and satisfaction with clinical practice (β =.124, p=.039). CONCLUSION: Research results suggest that the important variable for student nurses' practice burnout is perfectionism. Therefore education is needed to develop strategies to manage perfectionism and reduce practice burnout.