Korean Journal of Clinical Pathology  2001;21(6):465-470

The Relationship of Insulin Resistance to High-Sensitivity C-Reactive Protein.

Rojin PARK 1 ; Jeong Ho KIM ; Yong Seok YUN ; Young Duk SONG ; Kyung Rae KIM ; Kyung Soon SONG ; Oh Hun KWON ; Kap Bum HUH

Affiliations

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Keywords

Insulin resistance; High-sensitivity C-reactive protein; Type 2 diabetes mellitus; Glucose disposal rate; Inflammation

Country

Republic of Korea

Language

Korean

Abstract

BACKGROUND: Insulin resistance is known as the common denominator of risk factors of atheros-clerosis as well as the major pathogenic process of type 2 diabetes mellitus (DM). Recently some investigators indicated the relationship of chronic inflammatory reaction to atherosclerosis and insulin resistance. We examined the relationship between insulin resistance and high sensitivity CRP (hs-CRP) in Koreans. METHODS: Twenty-five patients with type 2 DM and eleven healthy men were examined. Glucose disposal rate (GDR, mg/kg/min) was determined as the index of insulin resistance by the euglycemic insulin clamp test with De Fronzo method. The serum hs-CRP level was determined by Behring nephelometric assay, fibrinogen by functional assay, and plasminogen activator inhibitor-1 (PAI-1) by ELISA. We also included 81 healthy subjects to determine the reference range of hs-CRP. RESULTS: The reference range (median) of hs-CRP was 0-5.20 (0.56) mg/L. The hs-CRP concentration was not significantly different between control and DM groups. The GDR of DM (3.8+/-1.7) showed significantly decreased value compared with normal (8.4+/-1.5) group (P<0.001). In all subjects, there was no significant correlation of GDR and hs-CRP. CONCLUSTIONS: There was no significant correlation of GDR and hs-CRP. We think the interventional prospective study with anti-inflammatory drug is warranted to elucidate the independent relationship between insulin resistance and hs-CRP.