Journal of Rheumatic Diseases  2013;20(4):270-274

doi:10.4078/jrd.2013.20.4.270

A Case of Psoriasiform Dermatitis Followed by Tumor Necrosis Factor Inhibitor Treated with Phototherapy.

Gyun Seop LIM 1 ; Hyung Nam KIM ; Bo Bae KIM ; Dong Hyun KIM ; Yun Sung KIM ; Hyun Sook KIM

Affiliations

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Keywords

Phototherapy; Psoriasiform dermatitis; TNF-alpha antagonist; Rheumatoid arthritis

Country

Republic of Korea

Language

Korean

Abstract

Although tumor necrosis factor (TNF)-alpha antagonist is a successful treatment modality for various autoimmune diseases, including rheumatoid arthritis (RA), ankylosing spondylitis and psoriatic arthritis, many adverse effects have been reported. Cutaneous adverse reactions of TNF-alpha antagonist include skin rash, urticaria, lupus like rash, seborrheic dermatitis and different kinds of psoriasiform dermatitis. We report a case of psoriasiform dermatitis during TNF-alpha antagonist treatment in a 50-year-old woman with RA. The patient has been treated with adalimumab. After 2 months, she developed pruritic erythematous eruption and desquamative lesions on the head and limbs, which were defined as psoriasiform change by a skin biopsy. These skin lesions are successfully treated with combination therapy, including cessation of adalimumab, corticosteroid and phototherapy.