Journal of Korean Neurosurgical Society  1999;28(8):1194-1198

Epithelioid Hemangioendothelioma.

Sung Rok HAN 1 ; Chong Oon PARK ; Dong Keun HYUN ; Young Soo HA

Affiliations

+expand

Keywords

Epithelioid hemangioendothelioma; Computed tomography; Magnetic resonance imaging; Histopathology; Immunohistochemistry

Country

Republic of Korea

Language

Korean

Abstract

Epithelioid hemangioendothelioma is a rare vascular neoplasm characterized by epithelioid tumor cells and borderline biologic behavior. We present a case of grade III malignant epithelioid hemangioendothelioma of the skull and brain parenchyme in a 58-year-old female. The tumor consisted of loose aggregates of epithelioid cells with a focal small nest pattern and tumor cells displayed frequent intracytoplasmic vacuoles and contained areas with significant atypia and mitotic activity(more than 2/10 HPF). Immunohistochemically, the tumor cells showed positive staining for facor VIII-RGA and vimentin. Radiological and histopathologic characteristics of this tumor with a review of pertinent literature is presented.