Journal of Korean Neurosurgical Society  1999;28(8):1208-1214

Pathogenesis of Cerebral Vasospasm.

Chang Taek MOON 1

Affiliations

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Keywords

Cerebral vasospasm; Subarachnoid hemorrhage; Nitric oxide; cGMP; Potassium channel; Endothelin; Protein kinase C

Country

Republic of Korea

Language

Korean

Abstract

Although cerebral vasospasm is the greatest cause of morbidity and mortality in patient who survive the ictus of subarachnoid hemorrhage(SAH), the pathogenesis of vasospasm remains unclear. However, recent advances in the research of vasospasm suggest that decreased vasodilator function and/or increased vasoconstrictor function are basic changes of cerebral vasculature after SAH. So, the present review will focus on the roles of nitric oxide(NO), cGMP, potassium channel, endothelin(ET), and protein kinase C(PKC) as they relate to SAH.