Journal of Bone Metabolism  2015;22(2):83-86

doi:10.11005/jbm.2015.22.2.83

A First Case of Osteomesopyknosis in Korea.

Bi Na JEOUNG 1 ; Jong Min KIM ; Gyoun Eun KANG ; Jang Hwan LIM ; Eui Hyun KIM ; Hyun Ae SEO

Affiliations

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Keywords

Axial osteosclerosis; Bone disease; Back pain

Country

Republic of Korea

Language

English

Abstract

Osteomesopyknosis is a rare sclerosing bone disorder of autosomal dominant inheritance. We report a first case of osteomesopyknosis in Korea. A 16-year old girl complained of diffuse back pain for 1 year. We performed physical examination, biochemical investigations and imaging studies. A radiograph of spine revealed rugger-jersey vertebra and sandwich vertebra. Bone specific alkaline phosphatase, osteocalcin and C-terminal telopeptides of type I collagen were normal. Only an axial skeleton involvement was shown on the whole body bone scan. This patient was diagnosed to have osteomesopyknosis. Osteomesopyknosis is characterized by normal level of bone turnover marker and an axial bone involvement. Osteomesopyknosis can be occurred in Korea and needs to be considered when patients, especially young patients, suffer from back pain and have only axial osteosclerosis.