Korean Diabetes Journal  2009;33(5):363-372

doi:10.4093/kdj.2009.33.5.363

Clinical Implications of Serum Biomarkers in Diabetic Cardiovascular Complications.

Jang Won SON 1 ; Hyuk Sang KWON

Affiliations

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Keywords

Atherosclerosis; Biological markers; Cardiovascular disease; Diabetes mellitus

Country

Republic of Korea

Language

Korean

Abstract

Diabetes is associated with increased risk of cardiovascular disease, with atherosclerosis responsible for most associated morbidity and mortality. Atherosclerosis often causes acute thrombotic events through plaque rupture and formation of platelet-rich thrombi. The principal clinical manifestations of atherosclerosis are coronary artery disease, ischemic stroke, and peripheral arterial disease. Endothelial dysfunction, oxidative stress, and low-grade inflammation are key features in the pathophysiology of atherosclerosis.