Korean Journal of Aerospace and Environmental Medicine  1999;9(2):207-214

Chromosome Aberrations and Sister-chromatid Exchanges in Workers Exposed to Mixed-organic Solvents in Shoe-making Workshops.

Jaechul SONG 1 ; Soo Jin LEE ; Sang Chul ROH ; Soo Jung SOHN ; Hye Young OH ; Chang Hwan PARK ; Eui Sik HAN ; Kwang Won HA

Affiliations

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Keywords

Organic solvents; Chromosome aberration; Sister chromatid exchange

Country

Republic of Korea

Language

Korean

Abstract

Chromosome aberrations and sister chromatid exchanges (SCEs) in lymphocytes of peropheral blood as an indicator which could evaluate the effects of mutagenicity after in human exposure to mixed-organic solvents were measured. This study was conducted using 33 shoe making workers occupationally exposed to organic solvents and 33 unexposed control. The results were as follows. 1. The mean air concentrations of n-hexane, toluene, ethyl acetate in working environment were 9.8-14.8, 31.7-45.4 and 4.4-7.6 ppm, respectively. 2. The frequencies of chromosome aberration in exposed workers to mixed-organic solvents and the unexposed were 1.12+/-1.24, 0.36+/-0.70, respectively and their differences were statistically significant (p<0.01). However, the SCE frequencies were not statistically significant between the both groups. 3. The frequencies of chromosome aberration and SCE were no statistically differences by sex, smoking and drinking.