Journal of Liver Cancer  2017;17(1):72-76

doi:10.17998/jlc.17.1.72

A Case of Hepatocellular Carcinoma with Pulmonary Metastasis Who Showed Complete Response by Cytotoxic Chemotherapy after Sorafenib Failure.

Hwa Sun PARK 1 ; Jae Young JANG ; Min Young BAEK ; Yong Kwon KIM ; Hyun Jin YOUN ; Su Young BACK ; Soung Won JEONG ; Sae Hwan LEE ; Sang Gyune KIM ; Sang Woo CHA ; Young Seok KIM ; Young Deok CHO ; Hong Soo KIM ; Boo Sung KIM

Affiliations

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Keywords

Hepatocellular carcinoma; Pulmonary metastasis; Cytotoxic chemotherapy; Sorafenib

Country

Republic of Korea

Language

Korean

Abstract

Hepatocellular carcinoma (HCC) is the 2nd most common cause of cancer related death in Korea and well-known malignancy with poor prognosis. Sorafenib is the first-line molecular targeted agent in patients with extra-hepatic spread of HCC. However, complete response is extremely rare in patients treated with sorafenib and the disease control rate is only 43%. We report a 53-year-old man with advanced HCC with pulmonary metastasis who showed complete response by cytotoxic chemotherapy with doxorubicin and cisplatin with relatively tolerable adverse effects after failure of treatment with sorafenib.