The Journal of Korean Society of Menopause  2010;16(1):23-28

Association between the Total Homocysteine Concentration and the Bone Marrow Density and Bone Turnover Rate in Postmenopausal Women.

Bom Taeck KIM 1 ; Byung Hoon AHN ; Kwang Min KIM ; Nam Seok JOO ; Chan Won KIM ; Do Seung KWON ; Duck Joo LEE

Affiliations

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Keywords

Homocysteine; BMD; Bone size; Bone turnover

Country

Republic of Korea

Language

Korean

Abstract

OBJECTIVES: Hyperhomocysteinemia is related to fractures in the elderlies. We assessed the relationship between serum homocysteine and bone mass, size, and bone turnover rate. METHODS: This study included 2,670 postmenopausal women who underwent periodic health examinations in Ajou University Health Promotion Center, between January 2002 and December 2003. Serum homocysteine, bone turnover markers and bone mineral density were measured RESULTS: Patient age, osteocalcin, 25-vit D, total lumbar BMD, total lumbar T-score, the lowest lumbar BMD, the lowest lumbar T-score, femur neck BMD, femur neck T-score, femur trochanteric BMD and femur trochanteric T-score showed a significant correlation with the serum total homocysteine. However, after adjusting for age, the only osteocalcin was significantly correlated with the serum total homocysteine, At the 3rd lumbar vertebra, the BMC, volumetric BMD and areal BMD had a significant correlation with the serum total homocysteine but the bony size and the volume were not significant. After adjusting for age, the 3rd lumbar BMD was significantly correlated with the serum total homocysteine. CONCLUSION: Serum homocysteine level is correlated significantly with bone turnover rate, less with bone mass but not with bone size.