Laboratory Animal Research  2014;30(4):151-160

doi:10.5625/lar.2014.30.4.151

Effects of pectin lyase-modified red ginseng extracts in high-fat diet-fed obese mice.

Hak Yong LEE 1 ; Kwang Hyun PARK ; Young Mi PARK ; Dae In MOON ; Hong Geun OH ; Dae Young KWON ; Hye Jeong YANG ; Okjin KIM ; Dong Woo KIM ; Ji Hyun YOO ; Se Chul HONG ; Kun Hee LEE ; Su Yeon SEOL ; Yong Sik PARK ; Jong Dae PARK ; Mi Kyung PYO

Affiliations

+expand

Keywords

High fat diet; red ginseng extract; hyperglycemia; dyslipidemia

Country

Republic of Korea

Language

English

Abstract

Red ginseng and its extracts have been used as traditional medicines and functional foods in countries worldwide. The aim of this study was to examine the bioavailability of pectin lyase-modified red ginseng extracts (GS-E3D), and the effects of GS-E3D on adipogenesis of 3T3-L1 adipocytes, as well as on metabolic disorders such as hyperglycemia, dyslipidemia, and fatty liver in high-fat diet fed obese C57BL/6 mice. Mice were divided into 5 groups: normal diet group, high fat diet-vehicle group, high fat diet + 0.1 g/kg GS-E3D (0.1-GS-E3D), high fat diet + 0.3 g/kg (0.3-GS-E3D), high fat diet + 1.0 g/kg (1.0-GS-E3D). Treatment of GS-E3D reduced differentiation of 3T3-L1 adipocytes with low cytotoxicity. In the animal model, compared to the high fat diet control, serum glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG, and leptin level were reduced in treatment animals in a dose-dependent manner. In addition, we found that GS-E3D could decrease total hepatic lipid droplets. These results suggest that GS-E3D, as a dietary supplement, has beneficial effects on obesity and may have useful effects in health-care products.