Journal of Bone Metabolism  2013;20(1):57-60

doi:10.11005/jbm.2013.20.1.57

A Case of CATCH22 Syndrome Diagnosed in Postmenopausal Woman.

Seung Kyung LEE 1 ; Min Jeong LEE ; Hyo Jin LEE ; Bu Kyung KIM ; Young Bae SOHN ; Yoon Sok CHUNG

Affiliations

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Keywords

Hypocalcemia; Hypoparathyroidism; DiGeorge Syndrome

Country

Republic of Korea

Language

English

Abstract

CATCH 22 Syndrome is caused by chromosome 22q11.2 microdeletion, characterized by developmental abnormalities of the third and fourth pharyngeal pouches. It has a prevalence estimated at 1:3,000-1:9,000. Most deletions occurs sporadic, but autosomal dominant inheritance observed in 6-10% of cases. CATCH22 often diagnosed due to hypocalcemia during neonatal period or decreased immunity or facial defect, so it is very rare being diagnosed CATCH22 in adulthood. We report a 57 year old female who referred to mental change due to hypocalcemia and is diagnosed CATCH22. She was presented with hypoparathyroidism, single kidney due to renal agenesis, and mild facial defect. Our patient responded well to calcium and vitamin D treatment and she is on follow-up in outpatient clinic.