Natural Product Sciences  2015;21(2):71-75

Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences.

Nguyen Huu TUNG 1 ; Takuhiro UTO ; Osamu MORINAGA ; Yukihiro SHOYAMA

Affiliations

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Keywords

Bupleurum falcatum; Umbellifeae; Quinic acid; Saikosaponin; Anti-proliferative activity

Country

Republic of Korea

Language

English

Abstract

In this study, phytochemical investigation on the aerial parts of Bupleurum falcatum resulted in the isolation of fourteen compounds including three quinic acid derivatives (1 - 3), five flavonoids (4 - 8), three monoterpene glycosides (9 - 11), and three saikosaponins (12 - 14). Compound 1 was first isolated from nature and unambiguously determined to be 3-O-feruloyl 5-O-caffeoylquinic acid on the basis of the extensive spectroscopic evidence. Biological testing revealed that saikosaponin A (12) and saikosaponin D (13) showed moderate antiproliferative effects on HL-60 and HepG2 cancer cell lines.