Korean Journal of Medical Mycology  2014;19(1):18-24

Chromoblastomycosis Caused by Fonsecaea monophora.

Byeong Su KIM 1 ; Jin Hwa CHOI ; Seung Hyun SOHNG ; Dong Hoon SHIN ; Jong Soo CHOI ; Moo Kyu SUH

Affiliations

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Keywords

Chromoblastomycosis; Fonsecaea monophora

Country

Republic of Korea

Language

Korean

Abstract

Chromoblastomycosis is a chronic subcutaneous mycotic infections caused by dermatiaceous fungi. Clinically, chromoblastomycosis presents frequently with erythematous or nodular plaque. In Korea, 10 cases of chromoblastomycosis have been reported and Fonsecaea pedrosoi is the most common agent. A 61-year-old woman who was diagnosed as chronic inflammatory demyelinating polyneuropathy 3 years ago, and had been treated with systemic corticosteroids and azathioprine, presented with pruritic, scaly erythematous plaques on the right forearm for 3 years. She had no history of trauma. Histological examination showed pseudoepitheliomatous hyperplasia, mixed granulomatous inflammatory cell infiltrate and multinucleated giant cells with sclerotic cells in the dermis. Tissue culture showed slowly growing, dark brown, velvety colony. DNA was extracted from the cultured colonies and the DNA sequence of the internal transcribed spacer (ITS) region of the clinical sample was matched for that of Fonsecaea monophora. The patient was treated with local heat therapy and topical terbinafine application.