A 75-year-old female patient received an intravenous infusion of moxifloxacin hydrochloride injection 0.4 g for prevention of infections after lumbar operation. About 10 minutes later, the patient developed sudden general discomfort, wet and cold skin, drenching sweats. Meanwhile her heart rate was 130 beats/min, breath rate was 26 times/min, and blood pressure was 57/37 mmHg. Anaphylactic shock caused by moxifloxacin was considered. Moxifloxacin was stopped immediately, ECG monitoring and oxygen inhalation through nasal catheter were given. Then, intravenous injection of adrenaline hydrochloride injection 0.5 mg, furosemide injection 10 mg, nitroglycerin injection 2.5 mg, and sublingual metoprolol tartrate tablet 12.5 mg were given successively. After 80 minutes, the patient′s symptoms relieved, with heart rate 88 beats/min, breath rate 18 times/min, and blood pressure 95/54 mmHg.