Chinese Journal of Arteriosclerosis 2025;33(9):803-809

doi:10.20039/j.cnki.1007-3949.2025.09.009

Mechanisms and Prospects of EGCG in the Prevention and Treatment of Atheroscle-rosis

Xueqi DAI 1 ; Guanjie ZHANG ; Jing LI ; Huiyu LONG ; Hui SUN

Affiliations

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Keywords

atherosclerosis; epigallocatechin-3-O-gallate; mechanisms of action; cardiovascular diseases

Country

China

Language

Chinese

Abstract

Atherosclerosis(As)is a chronic inflammatory vascular disease and serves as the pathological basis for various cardiovascular diseases.Epigallocatechin-3-O-gallate(EGCG)is the most abundant and biologically active com-pound in green tea,possessing multiple pharmacological effects such as anti-inflammatory,antiviral,and antioxidative stress properties.In recent years,studies have found that EGCG can regulate lipid metabolism,improve vascular endo-thelial function,and enhance plaque stability,demonstrating its potential value in combating As.This article provides a systematic review of the mechanisms underlying EGCG's anti-As effects,aiming to offer multi-faceted theoretical support for its further research and clinical application in the prevention and treatment of As.