Chinese Journal of Reproduction and Contraception 2022;42(3):318-323

doi:10.3760/cma.j.cn101441-20200713-00394

Research on the regulatory mechanism of PLK1 in oocyte meiosis and its similarities and differences between meiosis and mitosis

Bo YAO 1 ; Feng LIU 1 ; Xiaolong MO 1 ; Yanping REN 1

Affiliations

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Keywords

PLK1; Oocyte; Meiosis; Microtubule organizing center; Spindle formation

Country

China

Language

Chinese

Abstract

Polo-like kinase 1 (PLK1) is one of the members of the serine/threonine protein kinase family. In mitosis, PLK1 is involved in regulating centrosome maturation, chromosome condensation, kinetochore-microtubule attachment, and cytokinesis. It has been pointed out in some researches that PLK1 also has similar functions in meiosis in mammalian oocytes, but there is no systematic review on the role of PLK1 in the mechanism of meiosis regulation in oocytes. In this study, the regulating mechanism of PLK1 in oocyte meiosis and the similarities and differences between meiosis and mitosis were investigated systematically by the location of PLK1 in oocyte, and the role of PLK1 in chromosome condensation, microtubule organizing centers (MTOCs) depolymerization, the recruitment of γ-tubulin and Pericentrin, and activation of anaphase-promoting complex/cyclostome (APC/C). It will lay the foundations for the further research on the molecular mechanism of meiosis in oocytes.