Chinese Journal of Reproduction and Contraception 2020;40(3):250-254

doi:10.3760/cma.j.cn101441-20190404-00137

Research progress of regulatory T cells in female reproductive process

Yunian ZHANG 1 ; Haiqing TIAN 1 ; Xiaolin LA 1

Affiliations

+expand

Keywords

Regulatory T cell; Infertility; Follicular development; Immunological tolerance

Country

China

Language

Chinese

Abstract

Regulatory T (Treg) cells are a subtype of lymphocytes with immune suppressive function, and are abundantly expressed on ovarian and endometrium. They have the functions of regulating follicular development, suppressing immune response, promoting maternal-fetal immune tolerance and maintaining early pregnancy during reproduction. The abnormal expressing of Tregs is closely related to the occurrence and development of female reproductive diseases, and it is expected to become a new diagnostic marker and therapeutic target in reproductive medicine.