Objective:To analyze the current status of medication adherence and its influencing factors in infertility patients during in vitro fertilization and embryo transfer (IVF-ET) cycles, and to provide evidence and ideas for improving medication adherence and formulating relevant intervention measures in the future. Methods:A cross-sectional survey was conducted to investigate 120 patients who underwent IVF-ET using the patient's basic situation questionnaire, MMAS-8, general self-efficacy scale (GSES), social support rating scale (SSRS) and medical coping models questionnaire (MCMQ). And the SPSS25.0 software was used to analyze the results.Results:The compliance score of IVF-ET patients was 6.70±1.42, and 69.6% patients had low medication adherence. Multivariate regression analysis showed that the main factors affecting patient compliance were patient self-efficacy and medical response to the disease.Conclusion:The current status of IVF-ET assisted patient’s medication adherence need to be further improved. Nursing staff need to not only build on traditional measures such as education, but also strengthen the self-efficacy, guide their choice to face. And when the psychological pressure is too great to be faced, the patient should be guided to adopt an “avoidance” coping style to alleviate the pressure brought by the disease. We should develop effective interventions to improve medication adherence.