The Chinese Journal of Clinical Pharmacology 2024;40(21):3171-3175

doi:10.13699/j.cnki.1001-6821.2024.21.021

Research status of hydrogen sulfide in the prevention and treatment of gastrointestinal ischemia-reperfusion injury

Si-yu WU 1 ; Xu-tao SUN 1 ; Shuo CAO 1 ; Cai-yun MAO 1 ; Qi ZHOU 1 ; Yun-jia SONG 1

Affiliations

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Keywords

hydrogen sulfide; hydrogen sulfide donor; gastrointestinal ischemia-reperfusion injury; prevention and cure

Country

China

Language

Chinese

Abstract

Gastrointestinal ischemia reperfusion(I/R)injury is a major cause of high morbidity and mortality in patients with surgical trauma.At present,there are few studies on gastrointestinal I/R injury,so it is particularly important to find treatment methods for gastrointestinal I/R injury.As the third gas signaling molecule,H2S plays an important physiological and pathological role in the human gastrointestinal system.Recently,a variety of novel H2S donors such as ATB-344 and AP39 have shown therapeutic value for gastrointestinal I/R injury.Therefore,this article reviewed the treatment of gastrointestinal I/R injury by H2S donors and its mechanism of action,aiming to provide a new treatment method for gastrointestinal I/R injury,in order to provide a reference for clinical medication of gastrointestinal I/R injury.