Journal of Capital Medical University 2025;46(3):436-441

doi:10.3969/j.issn.1006-7795.2025.03.006

B cell receptor signaling pathway and its therapeutic implications in B-cell lymphoma

Jingwen WANG 1 ; Zhenjun LI 1 ; Liangcheng LYU 1 ; Xiaoyu YAO 1 ; Ning DING 1

Affiliations

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Keywords

B-cell lymphoma; B cell receptor; signal pathway; small molecule inhibitors; immunotherapy

Country

China

Language

Chinese

Abstract

B-cell lymphomas account for 70％-80％of non-Hodgkin lymphomas(NHL)and exhibit significant heterogeneity in genetic profiles,phenotypic characteristics,and clinical manifestations,posing substantial challenges for clinical management.The B-cell receptor(BCR)is a transmembrane receptor on the surface of B cells that plays a central regulatory role in B-cell development,activation,and adaptive immune responses.As a core mechanism driving malignant transformation in various B-cell malignancies,aberrant activation of the BCR signaling pathway,plays a pivotal role in B lymphoma pathogenesis.Dysregulated BCR signaling not only promotes tumor cell proliferation,survival,and anti-apoptotic capacity but also accelerates malignant progression.Consequently,researchers are vigorously exploring therapeutic strategies targeting BCR and its downstream pathways,including inhibitors of Bruton's tyrosine kinase(BTK)and PI3K,as well as direct BCR-targeted approaches.The central role of BCR signaling in lymphoma pathogenesis and treatment underscores its potential as a critical focus for future therapeutic development,offering new directions and hope for improved clinical outcomes.