Journal of Modern Urology 2025;30(11):911-917

doi:10.3969/j.issn.1009-8291.2025.11.001

Safety management of targeted-immunotherapy combination for renal cell carcinoma

Hailiang ZHANG 1 ; Dingwei YE 1 ; Anwaier AIHETAIMUJIANG 1

Affiliations

+expand

Keywords

renal cell carcinoma; targeted therapy; immunotherapy; adverse effect; safety management

Country

China

Language

Chinese

Abstract

In recent years,the combined application of targeted-immunotherapy has become a recommended treatment option for advanced renal cell carcinoma in various guidelines.However,although this strategy has significant therapeutic effects and survival advantages,it is associated with a variety of adverse reactions that cannot be ignored.Therefore,how to effectively manage adverse reactions and ensure the treatment safety has become one of the core issues.This article systematically reviews the adverse effects and management strategies,discusses the early identification of adverse reactions,monitoring methods,the design of individualized treatment plans and future development,aiming to provide practical safety management guidance and explore the direction of future development.