Chinese Journal of Arteriosclerosis 2025;33(8):721-728

doi:10.20039/j.cnki.1007-3949.2025.08.011

Progress in the treatment of endothelial dysfunction in atherosclerosis

Xinyu ZHANG 1 ; Ziyue XIE ; Zi'an WANG ; Yu LI ; Ruigong ZHU

Affiliations

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Keywords

atherosclerosis; endothelial dysfunction; pharmacotherapy

Country

China

Language

Chinese

Abstract

Atherosclerosis is a chronic vascular wall disease.The clinical manifestations are abnormal lipid depo-sition,fibrous hyperplasia,calcium deposition,etc.under the intima of the affected artery lesions.Its initial link is re-lated to endothelial cell dysfunction,which can be triggered and aggravated by different risk factors of atherosclerosis,in-cluding oxidative stress,hemodynamic abnormalities,endothelial cell senescence and inflammation,etc.Exploring the mechanism of endothelial cell dysfunction is conducive to the discovery of potential treatments for atherosclerosis.This ar-ticle summarizes the mechanism and research progress of drug therapy for endothelial cell dysfunction in atherosclerosis.