Chinese Journal of Psychiatry 2024;57(4):245-250

doi:10.3760/cma.j.cn113661-20230915-00061

Research progress on immune inflammatory mechanism of metabolic syndrome comorbidity of depression

Yangyu WU 1 ; Jianzhao ZHANG 1 ; Xiaodong SONG 1 ; Shuming ZHONG 1 ; Yanbin JIA 1

Affiliations

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Keywords

Depressive disorder; Metabolic syndrome; Immune inflammation; Pathological mechanism

Country

China

Language

Chinese

Abstract

The prevalence of metabolic syndrome(MetS) in patients with major depressive disorder (MDD) is significantly higher than that in healthy people. Metabolic disorder has been proven to be closely related to the onset of MDD, adverse treatment outcome and disease recurrence. Therefore, revealing the comorbidity mechanism of both is of great significance for treating MDD. Previous studies have focused on the role of abnormal cortisol levels mediated by hypothalamic-pituitary-adrenal axis disorder, but how this pathway is activated and regulated is still unclear. In recent years, with further research development, systemic inflammation induced by an abnormal immune system is considered the deep molecular mechanism of MetS comorbidity of MDD. This review aims to summarize the similar activation of innate immunity, adaptive immunity and immune signaling pathway between MDD and MetS and to provide a strong theoretical basis for follow-up mechanism exploration, drug research and intervention strategy search.